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Document 3185
DOCN M94A3185
TI Prevalence of HTLV-I/II antibodies among HIV-1-asymptomatic patients in
Sao Paulo, Brazil.
DT 9412
AU Casseb JS; Caterino-de-Araujo A; Duarte AJ; Inst. de Infect. Emilio
Ribas, Sao Paulo, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):133 (abstract no. PA0152). Unique
Identifier : AIDSLINE ICA10/94369390
AB OBJECTIVE: To determine the seroprevalence of HTLV-I/II antibodies in
HIV-1-asymptomatic subjects, and identify the major route of
contamination with these dual retroviruses. PATIENTS AND METHODS: A
cohort of 123 HIV-1-infected individuals in ambulatorial accompaniment
to study the natural HIV history at the Secondary Immunodefiencies
Ambulatory, Immunology Division, Hospital das Clinicas, University of
Sao Paulo; others 208 HIV-1-asymptomatic patients recently diagnosed as
HIV-1-infected at the Center of Counselling to Sexual Transmitted
Diseases and AIDS (COAS) of Sao Paulo city, and 60 HIV-1 seronegative
subjects presenting some risk behaviour to acquire these retroviruses
were analysed in this study. Serum samples obtained from individuals
were tested for the presence of HTLV-I/II antibodies using two ELISA
kits. (Retrotek-HTLV-I, Cellular Products, NY, USA and Hemobio
anti-HTLV-I, Embrabio, SP, Br). Sera dually positive were confirmed by
WB (Immunoblot WB anti-HTLV-I, Embrabio, SP, Br). Positive and
indeterminated sera were tested to WB 2.3 HTLV-I and HTLV-II (Cellular
Products Inc. NY, USA). The serological results obtained were analysed
according to risk behaviour for acquiring retrovirus and CDC
classification system, 1986. RESULTS: from a total of 331 HIV-1-infected
sera tested, 25 (7.5%) resulted reactive for HTLV-I/II antibodies in
both ELISA tests; 6 (1.8%) had WB positivity and 9 (2.4%) presented an
indeterminated WB profile. On WB 2.3 analysis, 7 (1.6%) confirmed HTLV-I
and 2(0.6%) HTLV-II infections. Among 60 HIV-I seronegative individuals,
none showed HTLV antibodies reactivity Among 36 IVDA, 1 (2.8%) presented
HTLV-I and 1 (2.8%) HTLV-II infection on WB 2.3 analysis, respectively.
These results contrast with those obtained previously, when IVDA with
AIDS presented at least 26.4% of HTLVs infections.
DE Acquired Immunodeficiency Syndrome/BLOOD/*COMPLICATIONS/ EPIDEMIOLOGY
Brazil/EPIDEMIOLOGY Cohort Studies Enzyme-Linked Immunosorbent Assay
Human HIV Seronegativity *HIV-1 HTLV-I Antibodies/*BLOOD HTLV-I
Infections/BLOOD/COMPLICATIONS/*EPIDEMIOLOGY HTLV-II Antibodies/*BLOOD
HTLV-II Infections/BLOOD/COMPLICATIONS/*EPIDEMIOLOGY Prevalence
Risk-Taking Substance Abuse, Intravenous Support, Non-U.S. Gov't
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).